Myeloid Differentiation Identity
Gene co-expression module in Macrophages
| Category | Developmental |
|---|---|
| Genes | 30 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 30 genes have a known function matching the annotation |
Why this annotation
Hub genes include ALOX5 (leukotriene biosynthesis), IL13RA1 (IL-13 receptor, type 2 immunity), IKZF1 (Ikaros, myeloid/lymphoid TF), PIK3AP1 (PI3K signaling in B/myeloid cells), CMTM7 (B-cell/myeloid surface), and PLXNC1 (semaphorin receptor on macrophages). Despite weak coherence, the combination of ALOX5, IL13RA1, and IKZF1 points toward a myeloid/monocyte differentiation identity program. CDK6 and SMARCA2 add chromatin/cell cycle context. Module is poorly defined but myeloid identity genes are most prominent.
Genes
ADCK2, ALOX5, ATP2C1, CCDC6, CDK6, CMTM7, DEF6, EEF2K, EOGT, ERAP1, GALNT7, HIVEP3, IKZF1, IL13RA1, IPO8, JDP2, PIGN, PIK3AP1, PLXNC1, PTPN22, PTPRA, RTN1, SETD7, SIDT2, SLC36A1, SMARCA2, ST14, SUCLG2, SYNE1, VGLL4
Most correlated modules
- Myeloid Innate Signaling · correlation 0.94
- TGF-beta Signaling · correlation 0.93
- Sphingolipid Membrane Homeostasis · correlation 0.93
- RNA Processing Transport · correlation 0.92
- Central Carbon Metabolism · correlation 0.92
- Monocyte-Mac Iron Transport · correlation 0.92
- Myeloid Receptor Signaling · correlation 0.91
- Ribosome Biogenesis · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.