EEF2K — Eukaryotic elongation factor 2 kinase
EEF2K belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EEF2K's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Translational repression RNA processing & translation | B3GALT5, CDHR1, FAM13A, PDCD4, PLCL2, PROM1, PTPRJ | View in SCUBA |
| Macrophages | Myeloid Differentiation Identity Developmental | ADCK2, ALOX5, ATP2C1, CCDC6, CDK6, CMTM7, DEF6, EOGT +21 more | View in SCUBA |
About the gene
| Synonyms | CaMKIII, eEF-2K |
|---|---|
| Chromosome | 16: 22206278-22288738 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase |
Function
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.