PIGZ — Phosphatidylinositol glycan anchor biosynthesis class Z
PIGZ belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PIGZ's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene Nuclear Transcripts Technical artifact | ADAMTSL1, KHDRBS2, LIN7A, OPCML, PAQR5, PLCL1, RALYL, RFLNB +3 more | View in SCUBA |
About the gene
| Synonyms | FLJ12768, MGC52163, SMP3 |
|---|---|
| Chromosome | 3: 196946356-196969060 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
| Biological process | GPI-anchor biosynthesis |
Function
Alpha-1,2-mannosyltransferase that catalyzes the transfer of the fourth mannose, via an alpha-1,2 bond, from a dolichol-phosphate- mannose (Dol-P-Man) to an alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-2-PEtn- alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3- phospho)-2-acyl-inositol (also termed H6) intermediate and participates in the twelfth step of the glycosylphosphatidylinositol-anchor biosynthesis. The presence of a fourth mannose in GPI is facultative, suggesting that it only exists in some tissues
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.