Fatty Acid Oxidation
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes are strongly enriched for mitochondrial and peroxisomal fatty acid beta-oxidation: CPT1A and CPT2 (carnitine shuttle for long-chain fatty acids into mitochondria), HADHA (mitochondrial trifunctional protein, 3 steps of beta-oxidation), ECHS1 (enoyl-CoA hydratase), ACAT1 (thiolase), ETFA (electron transfer flavoprotein), BDH1 (ketone body metabolism), ABCD3 (peroxisomal LCFA transporter), SDHB (ETC complex II). MAOA and PANK3 support broader mitochondrial metabolic activity. Module is significantly decreased in both UC and CD inflammation and restored by CD treatment, consistent with known suppression of colonocyte fatty acid oxidation in IBD. Topological neighbor to M88 (mitochondrial OxPhos), reinforcing shared mitochondrial metabolic program.
Genes
Most correlated modules
- Mature Colonocyte Metabolism · correlation 0.85
- Mitochondrial OxPhos · correlation 0.79
- Glycosylation & Membrane · correlation 0.78
- Colonocyte Senescence · correlation 0.75
- Lipid Xenobiotic Metabolism · correlation 0.74
- Fatty Acid Oxidation · correlation 0.73
- Cholesterol Biosynthesis · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.