CES2 — Carboxylesterase 2
CES2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CES2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Macrophage Lipid Sensing Lipid metabolism | ARL4A, ARL4C, BIRC2, DDX21, DDX24, DDX27, GPR183, IDI1 +12 more | View in SCUBA |
About the gene
| Synonyms | CE-2, CES2A1, iCE |
|---|---|
| Chromosome | 16: 66934444-66945096 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Serine esterase |
| Biological process | Lipid metabolism |
Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2- arachidonoylglycerol and prostaglandins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.