CPT1A — Carnitine palmitoyltransferase 1A
CPT1A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CPT1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | PPARA/FXR fatty acid oxidation Lipid metabolism | ALDH18A1, ANO10, DGKD, FAT1, FMO5, NDRG1, NR1H4, PPARA +4 more | View in SCUBA |
| Macrophages | Myeloid Receptor Signaling Innate immunity | ADGRE5, ANKFY1, ANKIB1, ATP1B1, DNAJC13, DOCK7, EPS15, GALNT1 +29 more | View in SCUBA |
About the gene
| Synonyms | CPT1, CPT1-L, L-CPT1 |
|---|---|
| Chromosome | 11: 68754620-68844410 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Fatty acid metabolism, Lipid metabolism, Transport |
Function
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity. Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl- CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation. Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.