PPIE — Peptidylprolyl isomerase E
PPIE belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPIE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Ribosome Biogenesis RNA processing & translation | ALDH6A1, COMMD2, CRCP, CTNNBL1, DDI2, DHX30, ENAH, FAM98A +23 more | View in SCUBA |
About the gene
| Synonyms | CyP-33, MGC111222, MGC3736 |
|---|---|
| Chromosome | 1: 39692182-39763914 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Isomerase, RNA-binding, Rotamase |
| Biological process | mRNA processing, mRNA splicing |
Function
Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.