Ribosome Biogenesis
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 32 genes have a known function matching the annotation |
Why this annotation
Top hub genes NOP14, UTP11, GRWD1, OSGEP are all involved in ribosome biogenesis and rRNA processing. NCBP2 (nuclear cap-binding), NSUN2 (RNA methyltransferase), RBMX2 (RNA binding), PPIE (cyclophilin/splicing), FAM98A (tRNA ligase complex), PRPSAP1 (purine biosynthesis supporting nucleotide supply for rRNA), DDI2 (protease/DNA damage). Enrichment in crypt colonocytes is consistent with high proliferative demand for ribosome production. Core coherence supports a tight program.
Genes
Most correlated modules
- Vesicular Trafficking · correlation 0.97
- Stem Cell Epigenetic · correlation 0.96
- Mitochondrial Maintenance · correlation 0.92
- Ubiquitin-Proteasome System · correlation 0.86
- Mitochondrial Ribosome · correlation 0.84
- RNA Splicing Regulation · correlation 0.83
- BEST4 Colonocyte Identity · correlation 0.80
- ER Stress & UPR · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.