ENAH — ENAH actin regulator
ENAH belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENAH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Caveolae-mediated Transcytosis Metabolite transfer | ADIPOR2, CAV1, CAV2, CCDC85A, CD320, EEPD1, EMP2, HIF3A +19 more | View in SCUBA |
| Goblet cells | Chromatin Remodeling chromatin regulation & transcription | CCAR1, FNBP1L, KDM1A, LMO4, PAIP1, PBRM1, RHOBTB3, RTF1 +2 more | View in SCUBA |
About the gene
| Synonyms | FLJ10773, MENA, NDPP1 |
|---|---|
| Chromosome | 1: 225486765-225653142 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.