CTNNBL1 — Catenin beta like 1
CTNNBL1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTNNBL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Interferon Stimulated Response Inflammation | AK3, AP2A1, CYB5R3, DRG2, EPSTI1, EXOSC8, GPANK1, GUSB +6 more | |
| Hematopoietic progenitor cells | Erythroid Progenitor Program Erythropoietic | ABCC5, MINPP1, NBAS, PDCD4, PDZD8, RNF130, SLC40A1, SNX5 +3 more | |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
| Monocytes | Secretory Vesicle Trafficking Vesicular traficking | ABHD17C, DHRS3, FAM20C, HMGA1, NRIP1, PCBP3, SEMA3F, STX1A +1 more | View in SCUBA |
About the gene
| Synonyms | C20orf33, FLJ21108, NAP, NYD-SP19, P14, P14L |
|---|---|
| Chromosome | 20: 37693955-37872129 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Predicted intracellular proteins |
| Biological process | Adaptive immunity, Immunity, mRNA processing, mRNA splicing |
Function
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.