RASA1 — RAS p21 protein activator 1
RASA1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RASA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell Coinhibition Immune regulation | BTLA, CASD1, CFAP36, DUSP14, FCHSD2, HIVEP2, IFNGR2, KLF7 +7 more | View in SCUBA |
| Macrophages | Golgi Vesicle Trafficking Vesicular traficking | ARMH3, ATG7, CCDC91, CDK17, CLASP1, COG5, COMMD10, COP1 +24 more | View in SCUBA |
| Neutrophils | General Homeostatic Regulation Housekeeping | ARID2, EXOC4, FBXL17, LARP4B, MCU, MGAT5, RAD51B |
About the gene
| Synonyms | CM-AVM, GAP, p120, p120GAP, p120RASGAP, RASA |
|---|---|
| Chromosome | 5: 87267883-87391931 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | GTPase activation |
Function
Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.