COMMD10 — COMM domain containing 10
COMMD10 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COMMD10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | ILC1 Inflammatory Activation Inflammation | ALOX5AP, CNOT7, ELAVL1, FKBP8, FNTA, IFI27L2, IL32, LPXN +11 more | View in SCUBA |
| Macrophages | Golgi Vesicle Trafficking Vesicular traficking | ARMH3, ATG7, CCDC91, CDK17, CLASP1, COG5, COP1, DIAPH2 +24 more | View in SCUBA |
About the gene
| Synonyms | PTD002 |
|---|---|
| Chromosome | 5: 116085016-116412762 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Function
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin- RING E3 ubiquitin ligase (CRL) complexes. May down- regulate activation of NF-kappa-B.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.