Golgi Vesicle Trafficking
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 33 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 33 genes have a known function matching the annotation |
Why this annotation
GBF1 (Golgi-specific Arf GEF), COG5 (conserved oligomeric Golgi complex), VTI1A (SNARE protein for vesicle fusion), CCDC91 (Golgi-associated), and COP1 (COPI coat/E3 ligase) collectively point to Golgi vesicle trafficking. FMN1 and CLASP1 add cytoskeletal (actin/microtubule) components that support vesicle transport. KDM4C/KDM6A are histone demethylases. ATG7 links to autophagy. SBF2 (myotubularin phosphatase) and SPRED2 (Ras inhibitor) add signaling. The Golgi/vesicle trafficking theme is the most coherent cluster among hub genes.
Genes
ARMH3, ATG7, CCDC91, CDK17, CLASP1, COG5, COMMD10, COP1, DIAPH2, DPYD, DYM, EXOC4, FMN1, GBF1, GTDC1, KDM4C, KDM6A, KIF13B, MCTP1, NCOA2, NSMCE2, PAN3, PTBP2, RASA1, SBF2, SPRED2, STAG1, STK3, VTI1A, ZBTB20, ZCCHC7, ZFAND3, ZNF407
Most correlated modules
- Endosomal Rab Trafficking · correlation 0.98
- Ubiquitin Proteasome Regulation · correlation 0.98
- MAPK Stress Kinase · correlation 0.97
- Rho GTPase Signaling · correlation 0.96
- Rho GTPase Signaling · correlation 0.96
- Transcriptional Kinase Regulation · correlation 0.96
- MITF Lysosomal Program · correlation 0.95
- Transcriptional Regulation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.