RASA4 — RAS p21 protein activator 4
RASA4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RASA4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent Arterial EC Endothelial cell development | ABCG2, ANKRD50, CAMTA1, CDH23, CTNNAL1, CYB5A, HLF, INMT +10 more | View in SCUBA |
| Monocytes | MHC II Antigen Presentation Innate immunity | ARHGEF10L, CD4, CD74, HLA-DQA2, HLA-DRB5, RTN1, SASH1, SETDB2 | View in SCUBA |
About the gene
| Synonyms | CAPRI, GAPL, KIAA0538 |
|---|---|
| Chromosome | 7: 102579646-102616756 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | GTPase activation |
Function
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.