RETSAT — Retinol saturase
RETSAT belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RETSAT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Mature Colonocyte Identity Nutrient processing | ACAA2, AHCYL2, C2orf88, C3orf85, CD177, CHP1, CNNM4, CTSA +14 more | View in SCUBA |
About the gene
| Synonyms | FLJ20296 |
|---|---|
| Chromosome | 2: 85341955-85354531 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.