Mature Colonocyte Identity
Gene co-expression module in Colonocytes
| Category | Absorption |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 23 genes have a known function matching the annotation |
Why this annotation
SLC26A3 (15.7x sen_colono) is the canonical colonocyte chloride/bicarbonate exchanger and a defining marker of mature surface colonocytes. MS4A12 (8.2x) is another hallmark mature colonocyte marker. CHP1 regulates NHE (Na+/H+ exchanger), CNNM4 is a Mg2+ transporter, SLC51B transports bile acids, and AHCYL2 participates in the methionine/adenosylhomocysteine cycle. PRR15, RETSAT, TMEM120A, PKIB, and CD177 are also enriched in mature colonocytes. The module represents the mature colonocyte ion transport and identity program, centered on chloride absorption.
Genes
Most correlated modules
- ESCRT Membrane Remodeling · correlation 0.92
- Brush Border Cytoskeleton · correlation 0.91
- Senescent Colonocyte Identity · correlation 0.89
- Senescent Stress Signaling · correlation 0.87
- Colonocyte Cytoskeletal Contractility · correlation 0.87
- Lipid Xenobiotic Metabolism · correlation 0.87
- Colonocyte Detoxification · correlation 0.87
- Senescent Surface Identity · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.