ACAA2 — Acetyl-CoA acyltransferase 2
ACAA2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACAA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Core energy metabolism Mitochondrial & OxPhos | CFL1, CYCS, GAPDH, ME2, P4HB, PPA1, PSME2, SOD1 | View in SCUBA |
| Gamma-delta T cells | Glycolysis & Proteasome Housekeeping | ANAPC15, APEH, C1QBP, CCDC167, CHMP2A, CLNS1A, ENO1, HINT1 +11 more | |
| Goblet cells | Colonocyte Metabolic Defense Mitochondrial & OxPhos | CAT, CRYBG1, GLIPR2, MLXIP, PKDCC, SAMD5, SEMA6A, ZFHX3 | View in SCUBA |
| Innate lymphoid cells | NK Cytotoxic Effector Cytotoxicity | APIP, B4GALNT1, CAMK4, CCL5, CCNG2, CD247, CD3E, DCXR +17 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | ABCF2, ANXA2R, BST2, CHST12, IRF9, LY6E, LYSMD2, NDUFC2 +6 more | |
| Smooth muscle cells | SMC Contractile Signaling Contractility | BOC, CELF2, PLEKHO1, PRUNE2, RGS2, SCARA3, SDC3 | View in SCUBA |
About the gene
| Synonyms | DSAEC |
|---|---|
| Chromosome | 18: 49782164-49813953 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Acyltransferase, Hydrolase, Transferase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta- oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.