CTSA — Cathepsin A
CTSA belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTSA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Lysosomal proteases Protein processing & ER | CD63, CD82, CNPY3, CTSC, CTSD, CTSZ, FUT8, GALNT1 +2 more | View in SCUBA |
| CD4⁺ T cells | Epigenetic regulation DNA/chromatin regulation | AFF4, ARID1B, DGKH, FUBP1, JARID2, PDCD6, SYNCRIP, TET2 +6 more | View in SCUBA |
| CD8⁺ T cells | Cytotoxic Gut Effector cytotoxicity | ATP8B4, CCND2, CD63, CEBPB, CSF1, GNLY, GNPTAB, GZMA +3 more | View in SCUBA |
| Enterocytes | Apical Na+/H+ transport Absorption | COL17A1, GNG12, LHFPL2, MICAL2, PLS1, SLC6A20, SLC9A3 | View in SCUBA |
| Gamma-delta T cells | γδT17 Effector Inflammation | AQP3, CCR6, CEBPD, COLQ, CTSH, EDEM2, GCHFR, IL23R +10 more | |
| Smooth muscle cells | Pericellular Proteolysis ECM remodeling | AHNAK2, BNC2, CRYBG3, HTRA1, MMP14, S100A16, SNX9, TMED10 | View in SCUBA |
About the gene
| Synonyms | GSL, PPGB |
|---|---|
| Chromosome | 20: 45890144-45898949 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Carboxypeptidase, Hydrolase, Protease |
Function
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.