REV1 — REV1 DNA directed polymerase
REV1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
REV1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Chromatin Remodeling Housekeeping | ADIPOR2, ADNP, AP2A2, APPL2, ATF2, CDK19, CNOT1, CTDSPL2 +14 more | View in SCUBA |
About the gene
| Synonyms | REV1L |
|---|---|
| Chromosome | 2: 99400475-99490035 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding, Nucleotidyltransferase, Transferase |
| Biological process | DNA damage, DNA repair, DNA synthesis |
Function
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.