CNOT1 — CCR4-NOT transcription complex subunit 1
CNOT1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CNOT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Pre-mRNA Splicing RNA processing & translation | BCLAF1, CENPC, CLK1, COG3, COPS2, DDX24, DDX3X, EPC1 +11 more | |
| Macrophages | Chromatin Remodeling Housekeeping | ADIPOR2, ADNP, AP2A2, APPL2, ATF2, CDK19, CTDSPL2, DOCK2 +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear-Cytoplasmic Transport Housekeeping | AP1G1, INO80D, JARID2, NAA50, NUP98, PLEKHA2, PLEKHM1, RANBP2 +3 more |
About the gene
| Synonyms | AD-005, CDC39, KIAA1007, NOT1, NOT1H |
|---|---|
| Chromosome | 16: 58519951-58629885 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein, Repressor |
| Biological process | RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation |
Function
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)- containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.