ADNP — Activity dependent neuroprotector homeobox
ADNP belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADNP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | GPCR-AKT-MAPK Signaling TCR Signaling | AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB, CLPTM1L +29 more | |
| Macrophages | Chromatin Remodeling Housekeeping | ADIPOR2, AP2A2, APPL2, ATF2, CDK19, CNOT1, CTDSPL2, DOCK2 +14 more | View in SCUBA |
About the gene
| Synonyms | ADNP1, KIAA0784 |
|---|---|
| Chromosome | 20: 50888916-50931437 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta- catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.