Chromatin Remodeling
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 23 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include PDS5B (cohesin complex, chromosome cohesion/DNA repair), KDM3B (histone H3K9 demethylase, chromatin), CTDSPL2 (CTD phosphatase-like, transcription regulation; enriched in prolif_mac), CNOT1 (CCR4-NOT deadenylase complex scaffold, mRNA decay), ADNP (SWI/SNF-associated chromatin remodeling), SMARCC1 (SWI/SNF core subunit), REV1 (translesion DNA synthesis), CDK19 (Mediator-associated kinase). The dominant theme is chromatin remodeling and epigenetic regulation (KDM3B, ADNP, SMARCC1, PDS5B, REV1, CDK19). Slight prolif_mac enrichment for CTDSPL2 is consistent with chromatin-level cell cycle regulation. Neighbor modules also show weak chromatin/signaling themes.
Genes
ADIPOR2, ADNP, AP2A2, APPL2, ATF2, CDK19, CNOT1, CTDSPL2, DOCK2, KDM3B, MAPRE2, MFHAS1, MYO5A, OXR1, PDS5B, REV1, SMARCC1, SUFU, TAF3, TBC1D15, TNFRSF21, TPP2, ZZZ3
Most correlated modules
- DNA Damage Response · correlation 0.98
- Post-transcriptional Regulation · correlation 0.97
- Rho GTPase Signaling · correlation 0.96
- Myeloid Receptor Signaling · correlation 0.96
- MITF Lysosomal Program · correlation 0.96
- Endosomal Vesicle Trafficking · correlation 0.95
- Sphingolipid Membrane Homeostasis · correlation 0.94
- Transcriptional Regulation · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.