RNASEH1 — Ribonuclease H1
RNASEH1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNASEH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Glycosylation & trafficking Protein processing & ER | AASDHPPT, ABHD12, ACTR1A, ANKRD35, AP1S1, ARRDC1, ATF6B, ATG5 +25 more | View in SCUBA |
| Gamma-delta T cells | RNA Surveillance/NMD RNA processing & translation | AFG3L2, ANKRD13A, ARPP19, BRD10, C5orf24, DNM1L, ERVK3-1, KCTD20 +8 more |
About the gene
| Chromosome | 2: 3541430-3558333 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Endonuclease, Hydrolase, Nuclease |
Function
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.