ANKRD13A — Ankyrin repeat domain 13A
ANKRD13A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANKRD13A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | RNA Surveillance/NMD RNA processing & translation | AFG3L2, ARPP19, BRD10, C5orf24, DNM1L, ERVK3-1, KCTD20, NR2C2 +8 more | |
| Macrophages | Centrosome & DNA Repair Cell cycle | BRCA2, CASP2, CBX5, CCDC14, CEP152, CEP78, CKAP5, CSE1L +34 more | View in SCUBA |
About the gene
| Synonyms | ANKRD13, NY-REN-25 |
|---|---|
| Chromosome | 12: 109999186-110039763 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.