RNA Surveillance/NMD
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes UPF1 (nonsense-mediated decay master regulator), PNRC2 (NMD enhancer), TARDBP (RNA binding/NMD-linked), RNASEH1 (RNA:DNA processing), and ZC3H7A (RNA binding zinc finger) converge on post-transcriptional RNA regulation and NMD. ARPP19 is a phosphatase inhibitor involved in cell cycle but also RNA regulation. DNM1L and AFG3L2 add mitochondrial fission elements, but the dominant coherent program is RNA surveillance/NMD. Moderate coherence consistent with slight mixing of RNA decay and mitochondrial subprograms.
Genes
AFG3L2, ANKRD13A, ARPP19, BRD10, C5orf24, DNM1L, ERVK3-1, KCTD20, NR2C2, OSBP, PNRC2, RNASEH1, RRP7A, STRN, TARDBP, UPF1, ZC3H7A
Most correlated modules
- Transcriptional Repressor Complex · correlation 0.90
- T Cell Migration · correlation 0.88
- Pre-mRNA Splicing · correlation 0.85
- Transcriptional Coactivation · correlation 0.84
- T Cell Phosphatase Signaling · correlation 0.83
- Spliceosome Regulation · correlation 0.81
- ER Protein Biogenesis · correlation 0.80
- Centrosome Organization · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.