ARPP19 — CAMP regulated phosphoprotein 19
ARPP19 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARPP19's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated effector Tcell Immune regulation | APOBEC3C, CISD2, CTSC, ENTPD1, GLUD1, IL2RB, LYST, MICAL2 +4 more | View in SCUBA |
| CD8⁺ T cells | Proteasome Degradation Housekeeping | CLTA, GNG5, HSBP1, NDUFB4, POLR2J, POLR2K, PSMB2, PSMB3 +2 more | View in SCUBA |
| Endothelial | Chromatin Cell Cycle DNA/chromatin regulation | BRD7, CCPG1, CMPK1, IPO9, MBD2, PDS5B, TM9SF2 | View in SCUBA |
| Gamma-delta T cells | RNA Surveillance/NMD RNA processing & translation | AFG3L2, ANKRD13A, BRD10, C5orf24, DNM1L, ERVK3-1, KCTD20, NR2C2 +8 more | |
| Macrophages | ER Morphology Stress Stress | ARMC1, ATL3, CMPK1, CYB5B, EIF2AK1, ELAVL1, ERGIC2, HDAC2 +8 more | View in SCUBA |
About the gene
| Synonyms | ARPP-16, ARPP-19, ARPP16, ENSAL |
|---|---|
| Chromosome | 15: 52547045-52569883 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Protein phosphatase inhibitor |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Inhibition of PP2A is enhanced when ARPP19 is phosphorylated. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.