RTN1 — Reticulon 1
RTN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RTN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Myeloid Differentiation Identity Developmental | ADCK2, ALOX5, ATP2C1, CCDC6, CDK6, CMTM7, DEF6, EEF2K +21 more | View in SCUBA |
| Monocytes | MHC II Antigen Presentation Innate immunity | ARHGEF10L, CD4, CD74, HLA-DQA2, HLA-DRB5, RASA4, SASH1, SETDB2 | View in SCUBA |
About the gene
| Synonyms | NSP |
|---|---|
| Chromosome | 14: 59595976-59870776 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins, Transporters |
Function
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.