SGPP2 — Sphingosine-1-phosphate phosphatase 2
SGPP2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SGPP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicle trafficking Housekeeping | AP2A1, APPL2, ARHGAP35, ATAD2, DHX30, DYRK1B, ERP44, FAM91A1 +21 more | View in SCUBA |
About the gene
| Synonyms | FLJ39004, SPP2 |
|---|---|
| Chromosome | 2: 222424543-222562621 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid metabolism |
Function
Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.