ATAD2 — ATPase family AAA domain containing 2

ATAD2 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ATAD2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	DNA Replication Cell cycle	ATAD5, BRCA1, CDCA4, E2F8, ESCO2, FANCI, FBXO5, LIG1 +4 more	View in SCUBA
CD4⁺ T cells	Vesicle trafficking Housekeeping	AP2A1, APPL2, ARHGAP35, DHX30, DYRK1B, ERP44, FAM91A1, FBXW11 +21 more	View in SCUBA
CD8⁺ T cells	S-phase Replication Cell cycle	CEP152, E2F7, E2F8, ESCO2, FAM111A, NCAPD3, POLQ, STIL	View in SCUBA
Endothelial	S-phase Proliferation Cell cycle	ATAD5, BRCA1, BRCA2, CENPH, CENPK, CENPU, DHFR, EZH2 +11 more	View in SCUBA
Gamma-delta T cells	S-phase Replication Cell cycle	ATAD5, BRCA2, CDT1, CENPH, CENPM, CENPU, CLSPN, DHFR +13 more
Goblet cells	Replication Fork Checkpoint Cell cycle	BRCA2, CENPM, CLSPN, DNAJC9, FANCI, LIG1, PKMYT1, RRM1	View in SCUBA
Hematopoietic progenitor cells	S-phase Progression Cell cycle	ATAD5, BRCA2, DNMT1, FANCI, LMNB1, RRM1, SMC2, TMPO +1 more
Macrophages	S-phase DNA Replication Cell cycle	ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN, DHFR +31 more	View in SCUBA
Natural Killer cells	DNA Replication Cell cycle	DHFR, FEN1, LIG1, MCM7, PCNA, TK1, TMEM106C, UHRF1	View in SCUBA
Neutrophils	S-G2-M Cell Cycle Cell cycle	CENPP, CNTRL, EZH2, LNPEP, MIS18BP1, RRM2, SMC4, TOPBP1 +1 more

About the gene

Synonyms	ANCCA, CT137, DKFZp667N1320, MGC29843, MGC5254, PRO2000
Chromosome	8: 123319850-123416350
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	Activator, Hydrolase
Biological process	Transcription, Transcription regulation

Function

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.