Vesicle trafficking
Gene co-expression module in CD4⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 30 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 30 genes have a known function matching the annotation |
Why this annotation
Hub genes are a diverse set of trafficking (TM9SF2, AP2A1, RAB35, GPR107), ubiquitin/signaling (FBXW11, RFFL, UNKL), and RNA/splicing (SRPK1, SAFB, RPP38) genes with no coherent single pathway. Uniform low expression, no dominant subset. This appears to be a generic activation-associated housekeeping module that rises with inflammation. No specific immune program emerges; classify as general housekeeping/cell maintenance.
Genes
AP2A1, APPL2, ARHGAP35, ATAD2, DHX30, DYRK1B, ERP44, FAM91A1, FBXW11, GPR107, IMPACT, INPP5F, MAP3K14, NKAPD1, PRDM8, RAB35, RCC1L, RFFL, RPP38, SAFB, SCRN2, SGPP2, SHOC2, SNAP29, SRGAP2, SRPK1, STON1, TM9SF2, UNKL, ZBTB17
Most correlated modules
- Cellular biosynthesis · correlation 0.92
- T cell Coinhibition · correlation 0.89
- ER-Golgi Trafficking · correlation 0.88
- Membrane trafficking · correlation 0.86
- NF-kB regulation · correlation 0.79
- Proteasome/translation · correlation 0.75
- T-cell activation · correlation 0.74
- DNA damage response · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.