SIAE — Sialic acid acetylesterase
SIAE belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SIAE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Glycosylation & Membrane Protein processing & ER | ALDH3A2, ARCN1, ATP6AP1, ATP8B1, CALCOCO2, CANT1, CD151, CERK +34 more | View in SCUBA |
About the gene
| Synonyms | CSE-C, LSE, MGC87009, YSG2 |
|---|---|
| Chromosome | 11: 124633113-124695707 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase, Serine esterase |
Function
Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates in the lysosomes (Probable). Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell- cell interactions, host-pathogen recognition, and tumor antigenicity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.