Glycosylation & Membrane
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 43 genes have a known function matching the annotation |
Why this annotation
Hub genes include CLTC (clathrin-mediated endocytosis), ATP8B1 (phospholipid flippase critical for bile acid homeostasis in enterocytes), GFPT1 (rate-limiting enzyme of hexosamine/O-GlcNAc pathway), CANT1 (Golgi nucleotidase supporting glycosylation), MAN2A1 (Golgi alpha-mannosidase II, N-glycan processing), SIAE (sialic acid acetylesterase). Additional genes HACD2 (fatty acid elongation), SERINC5 (serine incorporation into lipids), TMEM87B, RTN3 (ER membrane). The dominant theme is N-glycan processing and membrane glycosylation/lipid metabolism in the ER-Golgi. Neighbor to M88/M45 (mitochondrial), sharing SDHA/SQOR but the glycosylation theme is distinct.
Genes
Most correlated modules
- Cholesterol Biosynthesis · correlation 0.86
- Ubiquitin Signaling Response · correlation 0.83
- Fatty Acid Oxidation · correlation 0.78
- Mitochondrial OxPhos · correlation 0.77
- Lipid Metabolism · correlation 0.75
- ER Glycoprotein Folding · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.