CALCOCO2 — Calcium binding and coiled-coil domain 2
CALCOCO2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CALCOCO2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Effector Immune Activation Immune regulation | ABI3, APBB1IP, ASB2, BUB3, CASP4, COMMD7, CTSD, CXCR6 +7 more | View in SCUBA |
| Gamma-delta T cells | NK/T Cell Identity T cell maturation | AFTPH, ARHGAP17, ASXL2, ATF7IP, CD244, CLK3, GDI1, GPR174 +24 more | |
| Hematopoietic progenitor cells | Cytokine Feedback Signaling Inflammatory | ANKRD28, ATP8B4, BEX1, NOG, RHEX, SELL, SOCS3, SYT1 +2 more | |
| Innate lymphoid cells | NK JAK3 Signaling activation | ANKRD44, APLP2, ATP8B4, ERLEC1, FLOT1, FUT8, FYCO1, HADHB +10 more | View in SCUBA |
| Lymphatic endothelial | Glycolytic Housekeeping Housekeeping | CANX, CAP1, DPYSL2, DYNC1I2, EIF2S2, ENO1, GIMAP8, PGAM1 +1 more | View in SCUBA |
About the gene
| Synonyms | MGC17318, NDP52 |
|---|---|
| Chromosome | 17: 48831018-48866522 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Autophagy, Host-virus interaction |
Function
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.