TRIM4 — Tripartite motif containing 4
TRIM4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRIM4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | SR Kinase & RNA RNA processing & translation | ADHFE1, ATF2, BCAP31, C4orf3, CCPG1, CHKB, CLK2, EFR3A +17 more |
About the gene
| Synonyms | RNF87 |
|---|---|
| Chromosome | 7: 99876958-99919531 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Immunity, Innate immunity, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor RIGI, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.