SR Kinase & RNA
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 26 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 26 genes have a known function matching the annotation |
Why this annotation
CLK2 (CDC-like kinase that phosphorylates SR splicing factors) is the top hub and links this module to its neighbor M52's splicing theme. FASTK (mitochondrial RNA binding protein), METTL17 (mitochondrial methyltransferase), and SDHAF2 (succinate dehydrogenase assembly factor) add mitochondrial RNA/metabolic regulation. ATF2 and TBK1 contribute stress/innate signaling. SIN3B adds chromatin repression. The module is a moderate coherence mix centered on RNA kinase-mediated regulation of splicing and mitochondrial RNA processing, neighboring M52's splicing program.
Genes
ADHFE1, ATF2, BCAP31, C4orf3, CCPG1, CHKB, CLK2, EFR3A, FASTK, IFFO1, MAN1B1, METTL17, NCK1, PDCD7, PMS1, PSENEN, PURA, RDH14, RNFT1, SDHAF2, SIN3B, TBK1, TRIM4, TTC13, VPS26C, ZMYND11
Most correlated modules
- Chromatin Epigenetic Regulation · correlation 0.86
- DNA Damage Repair · correlation 0.84
- ER-Lysosomal Trafficking · correlation 0.81
- EOMES Effector Program · correlation 0.81
- RNA Splicing Processing · correlation 0.80
- mRNA Splicing Regulation · correlation 0.80
- T cell cAMP Signaling · correlation 0.77
- T cell Survival · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.