DNA Replication
Gene co-expression module in Colorectal carcinoma
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 17 genes have a known function matching the annotation |
Why this annotation
Core-coherent, 17 genes, all uniformly expressed. MCM3/MCM7 are replicative helicase subunits (MCM complex, S-phase licensing). PCNA is the sliding clamp for DNA polymerase. FEN1 processes Okazaki fragments. GINS2 is part of the CMG helicase active at replication forks. CDT1 licenses replication origins. RRM1 (ribonucleotide reductase) and TYMS (thymidylate synthase) supply dNTPs. DNMT1 methylates newly synthesised DNA. UHRF1 recruits DNMT1 to hemimethylated DNA. NASP is a histone H1 chaperone active during replication. ASF1B deposits histones onto newly replicated DNA. PCLAF (PCNA-associated factor) regulates PCNA at replication forks. HELLS (LSH) is a chromatin remodeler required for DNA methylation maintenance. TK1 phosphorylates thymidine (salvage pathway, S-phase). CENPM supports kinetochore function. DHFR provides folate for nucleotide synthesis. This is a canonical DNA replication / S-phase program.
Genes
Most correlated modules
- Mitotic Spindle · correlation 0.87
- Kinetochore Assembly · correlation 0.73
- Late Mitosis/Cytokinesis · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.