Mitotic Spindle
Gene co-expression module in Colorectal carcinoma
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Core-coherent module. TUBB/TUBA1B are structural tubulins of the mitotic spindle. CDK1 is the master mitotic kinase. ZWINT anchors the KMN kinetochore network. SPC25 is a kinetochore Ndc80-complex component. UBE2T is a ubiquitin E2 enzyme active in G2/M (FANC pathway and APC/C). RRM2 supplies dNTPs for DNA replication (S-phase). STMN1 (stathmin) destabilizes microtubules in interphase and is inactivated at mitosis. HMGN2 is a nucleosome-binding protein co-regulated with proliferation. The module integrates S-phase dNTP supply, tubulin dynamics, and kinetochore function — a broad mitotic spindle / S-to-M program consistent with the neighbor cluster.
Genes
Most correlated modules
- Kinetochore Assembly · correlation 0.94
- G2/M Transition · correlation 0.91
- DNA Replication · correlation 0.87
- Nucleotide Biosynthesis · correlation 0.84
- Late Mitosis/Cytokinesis · correlation 0.84
- Metaphase-Anaphase Transition · correlation 0.82
- G2/M Entry & PLK1 · correlation 0.80
- Pre-mRNA Splicing · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.