Kinetochore Assembly
Gene co-expression module in Colorectal carcinoma
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
All eight genes are core-coherent and uniformly expressed. CENPW and CENPN are centromere proteins essential for kinetochore assembly. MAD2L1 is the spindle assembly checkpoint effector. CKS1B drives CDK1/2 activity and SCF-Skp2 ubiquitin ligase. PBK (PDZ-binding kinase) phosphorylates histone H3 at mitosis. HMGB2 is a chromatin architectural protein elevated in cycling cells. DTYMK encodes thymidylate kinase (dTMP synthesis, S-phase). MZT1 is part of the gamma-tubulin ring complex for spindle pole body nucleation. Together these genes define a tight kinetochore assembly / spindle checkpoint program active in G2/M. Neighbor context (M19, M28, M37, M31, M52) confirms a cell-cycle neighborhood.
Genes
Most correlated modules
- G2/M Transition · correlation 0.95
- Metaphase-Anaphase Transition · correlation 0.94
- Mitotic Spindle · correlation 0.94
- G2/M Entry & PLK1 · correlation 0.89
- Late Mitosis/Cytokinesis · correlation 0.87
- Nucleotide Biosynthesis · correlation 0.82
- Pre-mRNA Splicing · correlation 0.75
- DNA Replication · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.