Late Mitosis/Cytokinesis
Gene co-expression module in Colorectal carcinoma
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 20 of 20 genes have a known function matching the annotation |
Why this annotation
All 20 genes are core members. MKI67 is the canonical late-G2/M proliferation marker. TOP2A decatenates chromosomes. CENPF, CENPE are kinetochore proteins. AURKB phosphorylates H3S10 and regulates chromosome segregation. TPX2 organises the spindle. TACC3, NUSAP1, ASPM, KIF20B, PRC1 are spindle midzone/cytokinesis regulators. ANLN (anillin) and ECT2 drive cytokinesis. CEP55 coordinates abscission. GTSE1 regulates microtubule stability post-mitosis. SMC2/SMC4 are condensin subunits. SGO1 protects centromeric cohesion. CDCA3 and ARHGAP11A regulate mitotic progression and cleavage furrow. This is the tightest and most comprehensive mitotic module in the batch, specifically representing late mitosis and cytokinesis.
Genes
Most correlated modules
- G2/M Entry & PLK1 · correlation 0.95
- Metaphase-Anaphase Transition · correlation 0.89
- Kinetochore Assembly · correlation 0.87
- G2/M Transition · correlation 0.86
- Mitotic Spindle · correlation 0.84
- DNA Replication · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.