Mitochondrial Beta-Oxidation
Gene co-expression module in Colorectal carcinoma
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes ECI1 (enoyl-CoA isomerase), HADH (3-hydroxyacyl-CoA dehydrogenase), UQCRC1 (ubiquinol-cytochrome c reductase core 1, Complex III), and NDUFB10 (NADH:ubiquinone oxidoreductase subunit, Complex I) define a mitochondrial fatty acid beta-oxidation and oxidative phosphorylation program. PFKL (phosphofructokinase) introduces glycolytic activity, consistent with the moderate coherence of a mixed metabolic module. GMDS (GDP-mannose dehydratase) participates in fucose metabolism. XBP1 and GPA33 link to the secretory/epithelial context of neighboring module M12. LMNA, ADAM15, and SERPINBs are peripheral members. The core signal is mitochondrial energy metabolism.
Genes
Most correlated modules
- ER Protein Folding UPR · correlation 0.77
- Epithelial Cell Adhesion · correlation 0.70
- Goblet Cell Secretory · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.