Goblet Cell Secretory
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes CREB3L1, MUC2, FCGBP, AGR2, AGR3, REG4, TFF1, TFF3, SPINK4, and ZG16B are canonical markers of differentiated goblet/secretory cells in the intestinal epithelium. CREB3L1 drives the ER stress-linked secretory program, AGR2/AGR3 are ER chaperones required for mucin folding, and MUC2 is the defining goblet cell mucin. SERPINA1, SLPI, and PLA2G2A reflect antimicrobial secretory output. The module is strongly coherent and uniformly expressed, consistent with a well-defined goblet cell differentiation program in CRC epithelium.
Genes
Most correlated modules
- Clathrin-mediated Endocytosis · correlation 0.64
- Epithelial Cell Adhesion · correlation 0.63
- Growth Arrest Senescence · correlation 0.59
- Mitochondrial Beta-Oxidation · correlation 0.56
- Gastric Mucous Metaplasia · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.