ER Protein Folding UPR
Gene co-expression module in Colorectal carcinoma
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
All top hub genes are canonical ER lumen residents: CALR (calreticulin, ER chaperone/Ca²⁺ buffer), PDIA3 and PDIA4 (protein disulfide isomerases), P4HB (PDI family), HSPA5/BiP (master ER chaperone, UPR sensor), HSP90B1/GRP94 (ER Hsp90), SEC61A1 and RPN1 (translocon complex), SURF4 (ERGIC cargo receptor), HDLBP (ER-associated). This is a textbook ER protein folding/unfolded protein response module. Strong coherence with all genes core/strong confirms tight co-regulation.
Genes
Most correlated modules
- ER Quality Control ERAD · correlation 0.82
- ER-Golgi Trafficking · correlation 0.80
- Ubiquitin-Proteasome System · correlation 0.79
- Epithelial Junctional Cytoskeleton · correlation 0.79
- Mitochondrial Beta-Oxidation · correlation 0.77
- Epithelial Cell Adhesion · correlation 0.76
- Integrin Adhesion Signaling · correlation 0.74
- Lysosomal Proteolysis ECM · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.