Epithelial Cell Adhesion
Gene co-expression module in Colorectal carcinoma
| Category | Ankiosis & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
LIMA1 (actin-binding LIM domain protein regulating cytoskeletal organization), AHNAK (giant scaffolding protein linking membrane to cytoskeleton), DSC2 (desmocollin-2, desmosomal cadherin essential for epithelial cell-cell adhesion), ATP1B1 (Na/K-ATPase beta-1, epithelial polarity), CDC42EP5 (CDC42 effector, cytoskeletal remodeling), and PLXNB2 (plexin, cytoskeletal/adhesion signaling) collectively describe an epithelial cytoskeletal and cell-adhesion maintenance program. As a neighbor to M8 (invasion), this module likely represents the baseline adhesion state opposing invasion.
Genes
Most correlated modules
- Epithelial Junctional Cytoskeleton · correlation 0.86
- STAT3 Oncogenic Signaling · correlation 0.86
- Tight Junction Integrity · correlation 0.80
- Colonocyte Differentiation · correlation 0.78
- Growth Arrest Senescence · correlation 0.78
- Complement Immune Evasion · correlation 0.78
- ECM Invasion Program · correlation 0.76
- ER Protein Folding UPR · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.