NF-κB Chemokine Response
Gene co-expression module in Colorectal carcinoma
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
The module is dominated by CXCL1, CXCL2, CXCL3, CXCL8 — canonical NF-κB-driven neutrophil-recruiting chemokines. NFKBIA is a direct NF-κB target and negative feedback regulator, confirming NF-κB pathway activation. F3 (tissue factor) and ANXA1 are also NF-κB targets with inflammatory roles. KLK10 and GCNT3 are expressed in inflamed colon epithelium. SERPINB1 is an anti-protease upregulated in inflammatory contexts. PLAC8 is expressed in myeloid/epithelial inflammatory states. This module represents a classic NF-κB-driven inflammatory chemokine response in CRC epithelial cells, neighbor to M65 which also features inflammatory/immune-response genes, supporting a shared upstream inflammatory signal.
Genes
Most correlated modules
- ECM Invasion Program · correlation 0.83
- Growth Arrest Senescence · correlation 0.77
- Acute Phase Inflammatory · correlation 0.71
- Clathrin-mediated Endocytosis · correlation 0.71
- Complement Immune Evasion · correlation 0.71
- Tight Junction Integrity · correlation 0.68
- Epithelial Cell Adhesion · correlation 0.67
- Epithelial S100/Keratin · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.