Myeloid Autophagy Stress
Gene co-expression module in Dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
SPI1 (PU.1) is the master myeloid transcription factor and a key hub. NRBF2 is a component of the PI3K-III/ATG14 autophagy initiation complex. CHMP2A is an ESCRT-III subunit involved in multivesicular body sorting and autophagy. NAAA is a lysosomal enzyme. APOL3 participates in innate immune defense and autophagy regulation. GCLC encodes the rate-limiting enzyme in glutathione synthesis, indicating oxidative stress response. SLAMF8 is a myeloid-expressed inhibitory receptor. CAMK2D links calcium signaling to myeloid activation. The module is enriched in cDC1, shows positive delta_inflammation (trending up in disease), and is reduced by treatment. Moderate coherence reflects a mixed but related program of myeloid transcriptional regulation with autophagy and oxidative stress components. Neighbor context: shares myeloid identity with M52 (SPI1 vs AIF1/LY86) but adds autophagy/stress regulation, consistent with a more activated or stressed cDC1 state.
Genes
Most correlated modules
- G1/S Cell Cycle · correlation 0.84
- Type I Interferon · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.