Type I Interferon
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
The module contains multiple canonical interferon-stimulated genes (ISGs): IFI16 (cytosolic DNA sensor, ISG), IFI35 (ISG35), BST2/tetherin (ISG, antiviral restriction), UBE2L6 (ISG15-conjugating E2 enzyme), NMI (N-myc interactor, IFN-inducible), DTX3L (PARP14 partner, ISG), CALCOCO2 (NDP52, selective autophagy receptor, ISG-regulated). GSTO1 and FKBP1A are co-regulated metabolic genes. The strong cDC1 enrichment (72.4x) and significant positive delta_inflammation in CD (0.753, sig.) are consistent with cDC1 being the primary IFN-producing/responding DC subset in gut inflammation. UBE2L6 and BST2 are among the most reliable ISG markers. Neighbor M103 (UPR) and M113 (ER chaperones) may co-activate with IFN signaling during viral/bacterial responses.
Genes
Most correlated modules
- ER Protein Folding · correlation 0.89
- Actin Polymerization · correlation 0.85
- ER Translocon Processing · correlation 0.82
- Myeloid Autophagy Stress · correlation 0.80
- SNARE Vesicular Trafficking · correlation 0.79
- Proliferating DC Mixed · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.