G1/S Cell Cycle
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
The top hub gene CCND3 (Cyclin D3) is a canonical G1/S cell cycle regulator enriched in prolif_DC (2.2x), and TMEM109 is also prolif_DC-enriched (2.3x). GRK2 and RGS19 regulate GPCR/G-protein signaling and can modulate cell cycle entry. SND1 is a transcriptional co-activator involved in cell proliferation. MSL3 mediates H4K16 acetylation, an epigenetic mark associated with transcriptional activation. GYG1 and GNPDA1 reflect metabolic support for proliferating cells. The dominant signal is G1/S cell cycle progression driven by CCND3, with supporting proliferative context from prolif_DC enrichment. Moderate coherence and weak membership of lower-ranked genes reflect a mixed module anchored by a cell cycle core. Neighbor M35 also shows prolif_DC enrichment, reinforcing a proliferation-associated neighborhood.
Genes
Most correlated modules
- Endosomal Retromer Trafficking · correlation 0.89
- Ribosome Biogenesis · correlation 0.89
- Myeloid DC Identity · correlation 0.88
- Oxidative Stress Response · correlation 0.88
- Actin Polymerization · correlation 0.85
- Lysosomal Vesicular Trafficking · correlation 0.84
- Myeloid Autophagy Stress · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.