cDC1 Transcription Factors
Gene co-expression module in Dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
BATF3 and IRF8 are the two master transcription factors that together specify cDC1 identity and are required for cDC1 development. Their co-expression as top hub genes defines this as a cDC1 transcriptional identity module. ASB2 is an E3 ubiquitin ligase involved in DC differentiation. KIF16B mediates early endosome positioning relevant to antigen processing. MAP2K6 (MKK6) activates p38 MAPK, a pathway downstream of cDC1 pattern recognition. SLC46A3 is a lysosomal transporter enriched in cDC1s. RGCC is a cDC1-enriched cell cycle regulator. The entire module is strongly cDC1-enriched (3-5x). Neighbor context: complements M46 (surface identity markers CLEC9A/XCR1) and M86 (phagosomal processing), forming the transcription factor arm of the cDC1 program.
Genes
Most correlated modules
- cDC1 Cross-Presentation · correlation 0.94
- Phagosomal Antigen Processing · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.