cDC1 Cross-Presentation
Gene co-expression module in Dendritic cells
| Category | Cross-presentation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
This module is anchored by the most specific cDC1 surface markers and functional machinery known: CLEC9A (DNGR-1, dead-cell sensing receptor defining cDC1), XCR1 (canonical cDC1 chemokine receptor), WDFY4 (essential for cross-presentation of cell-associated antigens), RUBCNL (RUBCN-like, involved in LC3-associated phagocytosis), CADM1 (cDC1 adhesion marker), TACSTD2 (cDC1-enriched), ENPP1, FUCA1 (lysosomal fucosidase), AIM2 (cytosolic DNA sensor active in cDC1s), EGLN3 (hypoxia-responsive prolyl hydroxylase). The extreme enrichment in cDC1 (up to 23x for TACSTD2, 20.8x for XCR1, 18.1x for CLEC9A) and the presence of WDFY4 specifically implicate cross-presentation machinery. Neighbor context: this is the most specific cDC1 identity/cross-presentation module in the batch, complementing the TF module (M144) and phagosomal processing module (M86).
Genes
Most correlated modules
- cDC1 Transcription Factors · correlation 0.94
- Phagosomal Antigen Processing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.