Phagosomal Antigen Processing
Gene co-expression module in Dendritic cells
| Category | Ag processing & presentation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes RAB32 and PPT1 anchor this module in lysosomal/phagosomal antigen processing. RAB32 is a RAB GTPase specifically required for phagosomal maturation and cross-presentation in cDC1s, controlling phagosomal pH to preserve antigen integrity. PPT1 is a lysosomal thioesterase involved in antigen processing. SNX3 mediates endosomal cargo sorting. DNASE1L3 is a cDC1-enriched DNase. GSTM4 and SERPINB6 provide cytoprotection during phagocytosis. FAH participates in amino acid catabolism. The module is predominantly cDC1-enriched, consistent with cDC1-specific phagosomal biology. Neighbor context: sits adjacent to the BATF3/IRF8 cDC1 differentiation module (M144) and the CLEC9A/XCR1 cDC1 identity module (M46), supporting a cDC1 phagosomal processing program rather than a generic lysosomal program.
Genes
Most correlated modules
- cDC1 Transcription Factors · correlation 0.88
- cDC1 Cross-Presentation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.